Abstract

In the present study, long non-coding RNA associated with hair growth in the goats was screened and identified using RNA sequencing technology, and its impact on the growth of Cashmere goats treated with fibroblast growth factor 5 was evaluated. GO and KEGG analysis confirmed that the best treatment condition of FGF-5 was 10-4 g/L treatment 72H (F4_72H). We studied cystathionine at high and low expression of LncRNA β synthase (CBS), cystathionine γ, the expression changes of cleaving enzyme (CTH), keratin 26 (k26) and keratin associated protein 11-1 (kap11.1). Results show that FGF-5 can suppress the showing of LncRNA in skin cells, lower the showing of target genes CBS and CTH, and promote the showing of related keratin genes k26 and kap11.1. FGF-5 may regulate Cashmere hair growth and development by promoting the showing of related keratin and keratin-associated protein genes (KAPs). This mechanism is achieved by suppressing the showing of the LncRNA gene and also by lowering the showing of the target genes CBS and CTH.

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